Craig Mazin said the tendrils growing inside a pipe in Jackson reflected humans disrupting the world while achieving industry: breaking the pipe was a noble effort to build more homes to house refugees but it has consequences, allowing the tendrils into Jackson.
During an interview with Josh Horowitz on his Happy Sad Confused podcast, Isabela Merced revealed that Kaitlyn Dever was given extra security on set. Abby remains a controversial character from the games, and as Merced explains, this makes Dever herself a target. To head off any potential threats, it was ensured that the actor had some extra protection. "There are people that actually genuinely hate Abby, who is not a real person. Just a reminder, not a real person. And so Kaitlyn had to be extra secured by security when it came to the filming of this." Merced revealed.
Gustavo Santaolalla, who composes the music for the series and games, also has a cameo appearance he's shown playing a ronroco, a stringed instrument similar to the guitar. Young Mazino and Isabela Merced took Santaolalla's instrument during filming to play, unaware it was his as he had not yet arrived.
Several changes were made to Abby's story in the series--such as her role as a Firefly being revealed in "Future Days" despite the information being withheld until much later in the game--as her playability in the game demanded different narrative revelations. Kaitlyn Dever found the change allowed viewers to understand Abby's rage in a more limited time.
Pedro Pascal and Bella Ramsey, who grew close during production of the first season, considered the separation of their characters Joel and Ellie "painful" and "lonelier" during filming for the second, though Pascal considered it "a very relatable fissure in relationships between parent and child". Pascal found Joel's "stubborn paralysis" fuel by fear of losing Ellie forced him to become vulnerable, which helped him address exhaustion in his own life.