Melissa Morris has achieved quite a weight loss transformation since appearing in My 600-lb Life season 1. When the Texas woman debuted on the show in 2012, she was 31 years old and over 650 pounds. Apart from other physical issues, Melissa's morbid obesity hampered her chances of conceiving a baby, leading her to think about her fitness and health. Soon, she met the iconic surgeon Dr. Younan Nowzaradan on the show, who helped plan her weight loss approach and pushed her to drop the extra pounds to qualify for the surgery.

Melissa's starting weight was 653 pounds, and her weight loss journey was very long. She consulted with My 600-lb Life's Dr. Nowzaradan in 2005, seven years before her story aired on the show. After many ups and downs, she dropped enough weight to qualify for the weight loss procedure, improving her life. Melissa had bariatric surgery and continued Dr. Now's program for several years.