Katherine Heigl and Josh Duhamel in Life as We Know It (2010)

Katherine Heigl and Sofía Vergara in New Year's Eve (2011)

Katherine Heigl and Ana Reeder in One for the Money (2012)

Robert De Niro, Diane Keaton, Katherine Heigl, Christine Ebersole, Patricia Rae, and Ana Ayora in The Big Wedding (2013)

Katherine Heigl in State of Affairs (2014)

Katherine Heigl, Patrick Wilson, Madison Wolfe, and Aiden Flowers in Home Sweet Hell (2015)

Katherine Heigl and Rosario Dawson in Unforgettable (2017)

Eric Dane, Aaron Stanford, Omahyra, and Dania Ramirez in X-Men: The Last Stand (2006)

Jessica Biel and Eric Dane in Valentine's Day (2010)

Sandra Oh and Elliot Page in Hard Candy (2005)

Aaron Eckhart and Sandra Oh in Rabbit Hole (2010)

Sandra Oh and Maya Erskine in Betas (2013)

Alexis Bledel and Jesse Williams in The Sisterhood of the Traveling Pants 2 (2008)

Richard Gere and Jesse Williams in Brooklyn's Finest (2009)

Anna Hutchison, Fran Kranz, Jesse Williams, and Chris Hemsworth in The Cabin in the Woods (2011)

Jesse Williams, Adam Pally, and Zoe Lister-Jones in Band Aid (2017)

Katherine Heigl and Brendan Fehr in Roswell (1999)

Christian Slater, Patrick Dempsey, Richard Grieco, and Costas Mandylor in Mobsters (1991)

Patrick Dempsey in Valentine's Day (2010)

Patrick Dempsey and Rosie Huntington-Whiteley in Transformers: Dark of the Moon (2011)

Renée Zellweger and Patrick Dempsey in Bridget Jones's Baby (2016)