High school lab partners Marshall and Frances uncover a conspiracy by big pharma and the government to suppress a rare mushroom that could cure all diseases.
Marshall is on the run, trying to flee New York; Frances confides to her boss, Rick, about the mushroom; Rick sends her to Marshall's farm to get more, but the situation gets out of hand.
Marshall buys a plot of land near a chemical waste site with a plan to grow more mushrooms; Frances rushes home from Europe after a huge development; Copano and Harrington investigate a connection between Marshall and Frances.
Marshall arrives in jail and learns that some very important people refuse to let him out, while danger lurks around every corner; Frances makes a fateful decision; Copano and Harrington pick up the pieces.
Marshall is rescued by another inmate, but now Marshall owes him a favor; desperate to get out of prison, he works on a risky plan when he runs into a surprising ally; Frances grapples with a life-changing event.
After being declared dead, Marshall Cuso and Amelia must resolve unfinished business by staying hidden. Francis deals with his supposed loss while facing unexpected changes in the development of Reutical mushrooms.