Chase and Cameron's relationship in House, M.D. started as a flirtation and turned into a "friends with benefits" situation before they eventually got married. Their marriage ended due to strain caused by Chase adopting some of House's bad qualities and a disagreement over ethics, ultimately leading to their divorce. Cameron admitted to having doubts about her love for Chase and brought divorce papers to the hospital, officially ending their marriage in House, M.D.

House, M.D. featured many romantic relationships over its eight seasons and 177 episodes, and one of the most significant romances in the show was between Dr. Robert Chase and Dr. Allison Cameron. Jesse Spencer and Jennifer Morrison played Chase and Cameron, respectively, and their characters were introduced in the pilot episode. Chase, a surgeon, and Cameron, an immunologist, were a part of Dr. Gregory House's diagnosticians team at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.