Get a clue: Millie Bobby Brown is back as the sleuthing younger sister of Sherlock Holmes (Henry Cavill) in “Enola Holmes 2.”

The sequel to the 2020 Netflix whodunnit finds Enola (Brown) once again solving mysteries in 19th century London while trying to launch her own detective agency. Based on Nancy Springer’s book series, the “Enola Holmes” franchise also stars Helena Bonham Carter, David Thewlis, Louis Partridge, and “Dune” breakout Sharon Duncan-Brewster. The film will be streaming November 4.

“Stranger Things” star Brown serves as a producer for the film, directed by Harry Bradbeer and written by Jack Thorne, both returning for the sequel. The franchise “may be the most important moment in my career so far because it’s something that I developed,” Brown told Entertainment Weekly. “It’s rewarding,” she added. “My age and gender has never defined [my job], so everyone on set really respected me and heard me. It...