- In a relationship with Jeffrey Dean Morgan since 2009. They have two children together - a son Augustus "Gus" Morgan (b. March 2010) and a daughter George Virginia Morgan (b. February 16, 2018). In a July 2015 interview with The Philippine Daily Inquirer, Morgan said that despite media reports to the contrary, he and Burton were not yet married but that they intended to wed when he could get enough time off from work.
- Was a bridesmaid at the wedding of One Tree Hill (2003) costar Danneel Ackles.
- When she got her role on One Tree Hill (2003) in North Carolina, she worked Monday through Thursday, and then returned every Friday back to New York to work on MTV.
- She has a cat named Poe (named after writer Edgar Allan Poe).
- Her One Tree Hill (2003) character, Peyton, works with her mother Ellie (Sheryl Lee), who battles breast cancer, on a compilation CD called "Friends with Benefit" to benefit the National Breast Cancer Foundation. That CD was actually released as a tie-in album, with a portion of its proceeds going directly to the National Breast Cancer Foundation to assist in their efforts to promote early-detection awareness among young women.
- Her hobbies are collecting antiques, knitting, and crocheting.
- Has toured with the USO.
- Started a podcast with One Tree Hill co-stars, Sophia Bush and Bethany Joy Lenz, titled "Drama Queens" in 2021.
- Her favorite musicians are Loretta Lynn, Dolly Parton, Elvis Costello, David Bowie, and Elvis Presley.
- Her favorite book is "Dandelion Wine" by Ray Bradbury.
- Close friends with One Tree Hill (2003) co-stars, Sophia Bush, Danneel Ackles, and Elisabeth Harnois.
- Her favorite TV show is Instituto McKinley (1999); she travels with the DVD boxed set.
- Appears in the Jack's Mannequin video "The Mixed Tape"
- She is the oldest of four children. She has three younger brothers--Billy, Johnny, and Conrad--whom she nicknamed Billy Awesome, Johnny Kickass, and C-Rock.
- Attended New York University.
- Was not allowed to watch MTV growing up.
- Had a series of miscarriages between the births of her son Gus in March 2010 and daughter George in February 2018.
- Two of her One Tree Hill (2003) co-stars were on Dawson crece (1998) with her: Chad Michael Murray (who played Lucas Scott) and Lee Norris (who played Mouth McFadden).
- Her favorite movies are Funny Lady (1975) and Quiero ser libre (1980).
- According to Teen People magazine, her worst vice is cussing.
- Her father, Bill, is an antique collector and her mother, Lisa, is a real-estate agent.
- Attended Fordham University at Lincoln Center.
- Appeared on cover of the Jan/Feb 2004 issue of American Cheerleader magazine.
- Ranked #77 on the Maxim magazine Hot 100 of 2007 list.
- Bought a gold 1986 Mercedes in March 2004.
- Residing in Wilmington, North Carolina, working on the 2nd season of One Tree Hill (2003). (septiembre de 2004)
- In Wilmington filming season 5 of One Tree Hill (2003). (agosto de 2007)
- Filming season 6 of One Tree Hill (2003). (junio de 2008)
- Working on the 4th season of One Tree Hill (2003). (agosto de 2006)
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