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An artifact known as the "Tablet of Order and Chaos" is shattered, causing problems with multiple Marvel realities. Madame Web calls on 4 versions of Spider-Man from 4 realities to assist her in bringing the realities back into balance.

An artifact known as the "Tablet of Order and Chaos" is shattered during a brief battle between Spider-Man and Mysterio, causing problems with multiple Marvel realities. Madame Web calls on four versions of Spider-Man from four realities to assist her in bringing the realities back into balance.—Jdmaxgaming

Spider-Man has fallen into Mysterio's trap, by shattering the 'Tablet of Order and Chaos'. Now, in order to save the multiverse, Spider-Man must team-up with Madame Webb and fix the MARVEL-multiverse before Mysterio becomes unstoppable with his newfound powers.—Johnny

Having shattered a powerful artifact, the bond between dimensions weakened, and it's up to Spider-Man and others like him to retrieve the artifact's parts that are scattered along their dimensions before someone causes a catastrophe.