- Dr. Meredith Grey: [voiceover] Remember when you were a kid and your biggest worry was like... if you'd get a bike for your birthday or if you'd get to eat cookies for breakfast. Being an adult: TOTALLY overrated. I mean seriously, don't be fooled by the hot shoes and great sex and no parents anywhere telling you what to do. Being an adult is responsibility. Responsibility really does suck. Really, REALLY sucks. Adults have to be places and do things and earn a living and pay the rent. And if you're training to be a surgeon, holding a human heart in your hands... Hello! Talk about responsibility! Kinda makes bikes and cookies look really really good, doesn't it? The scariest part about responsibility... When you skrew up and let it slip right through your fingers. Responsibility. It really does suck. Unfortunately once you get past the age of braces and training bras, responsibility doesn't go away. It can't be avoided. Either someone makes us face it or we suffer the consequences. And still, adulthood has its perks. I mean the shoes, the sex, the no parents anywhere telling you what to do... That's pretty damn good.
- Dr. Derek Shepherd: [Meredith and Derek are making out in the passenger seat of his car] You know, it sounds like the party's winding down. Yeah... Listen To Me!
- Dr. Meredith Grey: [laughing] What?
- Dr. Derek Shepherd: We should probably sneak inside now.
- Dr. Meredith Grey: We've done enough sneaking for tonight. It was good sneaking, but enough sneaking.
- Dr. Derek Shepherd: [pulling his shirt back up her shoulders] Yeah, I'd say we're pretty good sneakers.
- Dr. Miranda Bailey: [as they are about to kiss she knocks on the window] You mind moving this tail wagon? You blocking me in.
- Dr. Derek Shepherd: Apparently not good enough.
- Dr. Derek Shepherd: See it?
- Dr. Alex Karev: It's hard to miss.
- Dr. Derek Shepherd: A little more than he bargained for.
- Dr. Alex Karev: Maybe he's lucky. Maybe this is his way out of the hole
- Dr. Derek Shepherd: The hole? Interesting expression.
- Dr. Alex Karev: My father was into smack pretty heavy. He was a musician. It's tolerated in his line of work, not good for the family at home.
- Dr. Meredith Grey: I think, maybe I did something... to the heart, when I was holding it. I nodded off a little. Squeezed it.
- Dr. George O'Malley: The heart's a tough muscle; it can take a squeeze or two.
- Dr. George O'Malley: [to Hank] You and Izzie will give birth to very tall, blond people - kind of like Barbies.
- Dr. Isobel "Izzie" Stevens: [Izzie coming home the morning after the party, looking around] Holy Mother of Destruction...
- Dr. Derek Shepherd: [arrives at Meredith's house and finds her drinking tequila and dancing on her front lawn] You know, in some states you get arrested for that.
- [she sees him and smiles they walk over toward each other]
- Dr. Derek Shepherd: So you blew me off for a bottle of tequila. Tequila's no good for you. Doesn't call, doesn't write, it's not nearly as much fun to wake up to.
- Dr. George O'Malley: [to Izzie's boyfriend Hank] You and Izzie will give birth to very tall, blonde people. Kinda like Barbies.
- Dr. Isobel "Izzie" Stevens: Hank just needs to realize that doctors can have fun. We're not all workaholics with God complexes.
- Dr. Cristina Yang: We ARE workaholics with God complexes.
- Dr. Isobel "Izzie" Stevens: George, I need more ice and chips.
- Dr. George O'Malley: Who else did you invite?
- Dr. Cristina Yang: Izzie, we said the list was jocks only. Surgery, Trauma, Plastics. Who else?
- Dr. Isobel "Izzie" Stevens: Just some people from Peds
- Dr. Cristina Yang: You invited the preschoolers to Meredith's house. The next thing you'll say is you invited the shrinks.
- [Izzie looks away]
- Dr. Cristina Yang: She invited mental defects. This party's D.O.A.
- Dr. Cristina Yang: The bigger the party, the less time for bad sex with the hockey player.
- Dr. Isobel "Izzie" Stevens: Would you stop saying that?
- Dr. Cristina Yang: Ok
- Dr. Isobel "Izzie" Stevens: Hank and I have great sex.
- Dr. Cristina Yang: Mm hmmm
- Dr. Isobel "Izzie" Stevens: All the time.
- Dr. Cristina Yang: Mmm
- Dr. Isobel "Izzie" Stevens: In fact, we'll probably have sex after the party, or during the party.
- Dr. George O'Malley: As long as you clear it with Meredith.