Susanna Thompson, who had played the Borg Queen in earlier episodes of the show, was asked to reprise the role for the finale but was unavailable due to her commitment to the series Noch mal mit Gefühl (1999), so Alice Krige, who played the Borg Queen in Star Trek - Der erste Kontakt (1996), was brought in to play the role.
When Janeway walks out of the door from visiting Tuvok, you can hear the comms call for Doctor Pulaski. This could be the same Doctor Katherine Pulaski from season two TNG. It would stand to reason that it is, as Star Trek writers tend to drop in little nods on a regular basis.
This is Lieutenant Reginald Barclay's sixth appearance on "Star Trek: Voyager." He was only in five episodes of Raumschiff Enterprise: Das nächste Jahrhundert (1987).
According to Robert Beltran, the sudden romance between Chakotay and Seven of Nine was a result of a taunt he issued to producer Brannon Braga. Braga was involved with Seven of Nine actress Jeri Ryan at the time, and Beltran said he "didn't have the balls" to write a scene where he got to kiss her.
The episode won two Emmy Awards for Outstanding Special Visual Effects for a Series and Outstanding Music Composition for a Series (Dramatic Underscore).