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- Drew Barrymore presents human-interest stories, celebrity guests, lifestyle segments and field pieces, all driven by her infectious brand of humor and optimism.
- Satirical puppet series covering politics and pop culture through topical sketches, celebrity cameos and remote pieces.
- The black sheep of the family has spent a lifetime in the shadow of her prodigal younger sister. As the relationship with her mother takes a turn for the worse, things build to a boil that will leave one family member dead.
- In a Bolivian jungle, Adam and Caveman Rob pursue the fabled Executioner Wasp, Warrior Wasp, and Goliath Bird-Eating Tarantula. One causes a medical emergency, and another delivers a nightmarish bite that leaves Adam's arm partially paralyzed.
- Adam and Caveman Rob head to South Africa to face the giant Bark Scorpion, the tiny Uroplectes Scorpion, and the highly venomous Lion Fish. Big pain comes in small packages, and the effects of marine animals' toxins are truly the next level of pain.
- In Mexico, Adam and Caveman Rob tango with 2 torturous animals-including one that topped Justin Schmidt's pain scale. The guys up the stakes by covering their hands with hundreds of Harvester ants and 2 Pain Index records are shattered.
- In Africa, Adam and Caveman Rob search for the Nile Monitor Lizard and the Velvet Ant but are attacked by an even deadlier animal and are lucky to escape with their lives. The guys experience a brutal bite that makes them question their mission.
- A dangerous underwater hunt for the potentially deadly Scorpion Fish in the Baja California ocean leads to a toxic sting that puts Adam in danger and matches the highest pain score to date, while the Toe biter results in the weirdest pain profile yet.
- The guys head to Bali to test the Rove Beetle, and then the Fire Urchin.
- The guys encounter two creatures of the Amazon: The Paraponera clavata aka The Bullet Ant, and the Red-Bellied Piranha.
- Adam and Caveman Rob wrap up the season in Indonesia, with the two worst bites to date, from a Giant Asian Centipede and a 16-foot Reticulated Python. Vomiting, stitches, and rivers of blood make them ask if they are able to continue their research.
- This special episode spotlights the most compelling and dangerous moments from Adam and Caveman Rob's journey to expand upon Justin Schmidt's original pain index.
- The Slatons are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to because of her weight; white 32-year-old-Tammy is one step away from being confined to her bed.
- Amy and Tammy go to Atlanta to meet Dr. Procter to discuss weight-loss surgery; Dr. Procter gives Tammy a hefty weight-loss goal before he will approve her for surgery; the dietitian has more bad news for Amy.
- Amy and Tammy eagerly begin their weight loss journey. Sticking to their diets is a matter of life and death but proves to be a real struggle; the pressure to reach their goals culminates in a huge fight that threatens their diets and their relationship.
- After a stressful first month of dieting, the sisters head back to Atlanta for their one-month check-in with Dr. Procter to find out if they are on the right path to their weight goals. The results force Amy to make a difficult decision.
- Amy decides to have a real wedding ceremony because if she gets approved for surgery, she's afraid she may not survive. After the wedding, the sisters head to Atlanta hoping for a life-changing final weigh-in.
- Amy undergoes gastric bypass surgery to change her life, but endangers herself by not sticking to the post-op diet. Tammy seeks support from her love interest, Jerry. Two months later, the sisters reveal the changes they've made to family and friends.
- Amrit meets the Alternative Folk trio JEMS, comprised of Emily Colombier, Sarah Margaret Huff, and Jessica Rotter, inside the world famous recording complex Village Studios in West Los Angeles. Within Studio D, the same space that Fleetwood Mac helped design prior to recording their defining record 'Tusk', the JEMS came together to record their self-titled debut album in a single day, which helped define them as a band. Revisiting that space, Amrit discovers why these three artists have set aside their rising solo careers to unite into a group that LA Mag has listed as one of the next bands to watch from LA. After demonstrating to Amrit how they compose their unique harmonies, the JEMS take to the Skyline Stage high above Downtown Los Angeles for an exclusive performance.