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1-36 of 36
- A drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- Nurse Jackie Peyton is a hard working and dedicated ER nurse. She has a bad back, is married with two kids, but fools around and puts altogether too many hours in at work. She also has good judgment and knows more than some of the doctors. When she tells Dr. Cooper that she suspects a bicycle messenger brought in following an accident of having a brain bleed, he blows her off. She decides that something good will come out of the situation regardless. Similarly, when she learns that a diplomat who attacked a hooker will not be charged because of his diplomatic immunity, she has a solution for that as well.
- Jackie is spending time with her family at the beach but still shows that she's in charge. At the hospital, Gloria is concerned with the growing disappearance of drugs and gets Jackie to give training to staff on how the properly use the dispensing system. Dr. Cooper lodges a formal complaint against her and she comes within inches of being shot when a deranged patient fires their gun at no one in particular. Eddie is still trying to contact her but she ignores him completely. Until he finds a way to get her attention that she simply cannot avoid.
- Jackie is still incensed at having found Eddie in her house and tells him to stay away; he's not very receptive to the idea. Zoey performs brilliantly when a young child is brought in unable to breathe. A patient with stage 3 lymphoma is brought to the hospital but Dr. Cooper doesn't react well to Jackie's suggested treatment. She decides to help him out anyways. Dr. O'Hara and self-confessed sex addict Sam take it to the next level.
- Everyone at the hospital is put out - especially Dr. O'Hara - when Dr. Cooper is listed in a monthly magazine as one of the 25 best doctors in Manhattan. Jackie is less than pleased when Kaitlin shows up on a play date at her house. She's even less pleased when Kaitlin sees her snorting a line. At the hospital, she's almost caught taking drugs out of the dispensary using Zoey's access number. Back at home, she's dumbfounded when she sees who husband Kevin's new friend is.
- After a disastrous family vacation, Jackie returns to work for a day of reckoning. The mounting pressures and conflicts in her personal and professional lives reach a boiling point. Unexpected alliances lead to revelations that even Jackie can't avoid. Between Dr. O'Hara, Eddie, Kevin and the drug dealer, the wagons are circling around Jackie Peyton.
- Post-birthday party, Fiona busts her lip open on her cast and Dr. O'Hara and Jackie stitch her up in the Peyton kitchen. Jackie notices Sarah Khouri's philandering behavior and brings up her concerns to Dr. O'Hara. Libby Sussman, the uber-patron of All Saints, is brought into the ER.
- After avoiding Eddie, O'Hara and the drug dealer who has come looking for his stolen pills, Jackie takes off early for a family vacation upstate. But when Jackie misplaces the stash of pills she brought to get her through the vacation, she starts to unravel bit by bit.
- Jackie deals with Fiona's teacher's concerns and suspicions about her busted lip and cast. Dr. Cooper sets his friend Georgia up with Eddie. Dr. O'Hara, having once again ended things with Sarah, takes comfort with spending time with Jackie and her family in Queens.
- Jackie is discovered getting a phony prescription, while Eddie returns to All Saints, and Coop laments the end of his star-making media campaign.
- Dr. O'Hara shows up at work still high on the Ecstasy she took the night before. Jackie deals with a young boy who may have a serious respiratory problem. His parents are thrilled when Jackie says they can do the necessary tests at All Saints but may have sent them home too early. Having recovered from his suicide attempt, Eddie visits Jackie's husband Kevin at the bar. Nurse Sam begins to ask if either Jackie or Dr. O'Hara have a drug problem. Dr. Cooper has taken to twittering and it's driving Jackie crazy.
- Jackie is mad a husband Kevin when he reveals that he went to the movies with Ginny Flynn and the kids during the children's play date. Jackie decides to sleep on the couch. At the hospital, Gloria Akalitus is still concerned about the seepage in the drug lockup and posts a security guard at the machine, which doesn't seem to do much good. Sam still pursues Dr. O'Hara, who saw it all as a one night stand. O'Hara also reveals to Jackie that she knows a famous international TV news correspondent. Akalitus asks Dr. Cooper if he will be the face of a new promotional campaign directed at patients who have the ability to pay.
- Jackie sleeps with Eddie at his apartment and tells him to stop seeing Kevin. Posters with Dr. Cooper's face are plastered all over the city, much to the disgust of Jackie and Dr. O'Hara. Jackie treats a female Iraq war vet with PTSD. Dr. O'Hara's ex, Sarah Khouri, comes to town and they're back on. With Eddie and the Pill-O-Matix becoming less reliable sources, Jackie finds ways to get pills. Eddie ignores Jackie's request and invites Kevin out. Jackie allows Fiona to have a fake cast on her arm for her birthday.
- Jackie tells Kevin she wants to send Fiona to Immaculate with Grace. Kevin makes Jackie promise not to accept money from Dr. O'Hara. Jackie rents a P.O. Box in order to safely receive her secret credit card bill that she's now using to pay for prescriptions.
- Jackie's marriage is strained, as is her relationship with O'Hara after the intervention; Akalitus warns the staff that nearby hospitals have closed down, straining the staff and resources; Zoey publicly confesses her affair with Lenny.
- The Peytons meet with Grace's psychiatrist Dr. Bowen. When Jackie asks Eddie if he can fill Grace's scrip, he's cagey. Akalitus pulls Jackie off a case and tells her that she's putting her on probation. O'Hara and Jackie argue in front of the staff. Coop asks Akalitus if he can reserve the chapel for his wedding. Kevin promises to be home but doesn't make it back until after Jackie is asleep.
- Kevin takes off to batting practice where he meets Eddie. Eddie is sure Kevin knows about him and Jackie. Jackie, still sober is trying to get through her probation. Coop has a hard time getting Eddie to agree to be his best man. Zoey throws a party for Nurses Appreciation Week. Kelly and Jackie tag team a trauma where Jackie is forced to confess her probation.
- Akalitus is all over the staff: HR has mandated a urine sample from all the nurses. Jackie keeps dodging her. Coop's wedding is today and Jackie has forgotten to get the cake. Jackie is avoiding the inevitable conversation her husband is determined to have with her. Coop's bride stands him up at the altar. Akalitus finally gets Jackie to take a pee test just as Kevin arrives at the hospital.
- Eddie tells Jackie he can't keep lying to Kevin, whom he now considers a real friend. Akalitus announces that All Saints is vying for a visit from Michelle Obama and confides to Jackie that O'Hara is looking for work at another hospital. Coop tries to bury the hatchet with Sam. The rift between Jackie and O'Hara softens when Jackie tells her that she'll follow her to any hospital just to be near her. Kevin tells Jackie his buddy Eddie called and is out of a job and asks if she can put in a good word for him at All Saints.
- Much to Jackie's surprise, Kevin's younger sister, Tunie, shows up in the girls' bedroom, freshly hungover and tragically heartbroken after being dumped by her pilot boyfriend. On their way to work, Jackie tells Eddie she thinks Kevin installed Tunie to monitor her in the wake of his intervention. Lenny prepares Zoey a romantic picnic lunch only to crack her tooth when she bites into a sandwich where he's hidden his house key. Zoey talks things over with God, who's set up a makeshift piano bar in the ambulance bay. At the hospital, a Jewish Orthodox husband fights with his in-laws to have his critically injured wife moved to Beth Israel for a necessary operation. Later, bedlam ensues in the ER when two street meat vendors are brought in after a comically brutal turf war.
- Jackie's back in the swing of things, having re-hidden her stash of pills in the basement and mended fences with O'Hara. Zoey's working her first double and Jackie worries about her burning out. Lou, an out-of-work salesman, comes into the hospital and wins everyone over. O'Hara accepts the title of ER chief, which sparks a competitive streak in Coop. Kevin invites Eddie to a backyard barbecue to celebrate his new job. When Jackie gets home, she sees empty closets and drawers and panics-did Kevin leave her? She finds out he went to an Al-Anon meeting and the drawers are emptied because of a clothing drive at the school. Jackie asks Kevin to walk to the parish with her; she thinks they mistakenly gave away some sentimental items. She digs through the box of Grace's baby clothes to find what she was looking for-tiny mittens with bags of pills stashed inside.
- Jackie is on edge after realizing the stash of pills she stole from Bill the epileptic drug dealer is quickly dwindling. With a head of steam, Jackie confronts Eddie about his recent text exchanges with Kevin's younger sister, Tunie. Eddie maintains that it's completely innocent, while making the point that Jackie has no leg to stand on. Coop remains determined to battle O'Hara for the ER Chief title, but suffers a huge emotional blow when his mothers announce they're divorcing. Lou, the down-on-his-luck salesman, returns to the ER much worse for the wear. Akalitus enlists Jackie and Thor to help her ferry the Virgin Mary statue to Eddie's storage room, where it will be safe from repossession during the Catholic Church's impending de-consecration. Later, Jackie and O'Hara spar over whether to confront a belligerent mother who's making false claims about her daughter's need for treatment in order to stay on public assistance. At the end of a long, grueling day Jackie hits a new low when she makes her first illicit drug transaction with Bill.
- As Jackie's supply of pills starts to dwindle, her strategies become more intense and secretive. At All Saints, the saints from the chapel are being removed and carted off by the diocese. Between this, the lack of pills, her spiraling lack of control, and the saints leaving the building, Jackie finds herself unable to even walk through her own front door at the end of the day.
- Jackie soothes Grace's anxiety about the upcoming saint pageant. Kelly continues to win over the All Saints crew. Zoey connects with a twelve-year-old boy whose mother was brought in as a drug overdose. A Native American patient momentarily lifts Coop's depression. Jackie pockets a Fentynal delivery that was meant for Oncology. Kevin confronts Jackie with the dental floss/drug stash he found.
- Jackie visits Bill at his diner only to find that he has no pills for her. While helping Akalitus, Thor helps her face a deeper fear. Two drunk high school girls arrive in the ER after one of them face plants on the sidewalk. Coop is attempting to throw away his childish things that have cluttered his office. Jackie needs to get to Immaculate Virgin to see Grace perform in the Saint Pageant.
- With Jackie's drug hookup crushed under a truck, she's run out of pills. Eddie confronts Kelly about the missing Fentanyl patches. Kelly follows protocol to the letter. Coop sets his sights on an old girlfriend. Zoey assesses the seriousness of her relationship with Lenny. O'Hara finally settles down enough to purchase an apartment. Jackie finds what she needs on the walk home from work.
- Jackie realizes she needs professional help, while All Saints is taken over by a corporation whose new director makes a shocking personnel change. Kevin does not react well when he learns the truth about Jackie and Eddie.
- Jackie covers for Cruz when he has a panic attack. Zoey surveys her coworkers for the best way to conduct a breakup. Akalitus enlists the staff in an elaborate charade when her mentor enters the hospital, suffering from dementia.
- The firing of her colleagues, Grace's refusal to go to school, and an overflowing emergency room full of patients redirected from another hospital push Jackie to finally seize control of the E.R. and run it her way.
- Jackie reveals her rehab stint to Cruz and Eddie offers support for Jackie's case during his deposition to Kevin's lawyer. O'Hara finally leans on Coop during an OB/GYN appointment.
- Jackie learns that Grace knows the truth about rehab and races to tell Kevin before he hears about it from their daughter. She asks Charlie to meet her at an AA meeting but he shows up drunk.
- Worried about her daughter, Jackie leaves rehab early against her therapist's advice. Zoey has second thoughts about her relationship with Lenny.
- Jackie detoxes in rehab and forges a surprising alliance with 17-year-old fellow addict Charlie. Director Cruz's innovations continue to irritate everyone on the All Saints staff except for Coop.
- Missing her family and adjusting poorly to single life, Jackie invites Kevin to meet her at a café for lunch. An attempted double suicide trauma case comes into the E.R. Zoey looks for a new roommate.
- Jackie has a disturbing dream about using again. Zoey loses her engagement ring and questions her feelings for Lenny. O'Hara takes action on Jackie's behalf when Kevin sues for full custody.
- Cruz purposely pushes Jackie to the breaking point, and then uses her reaction as grounds to fire her. Jackie enrolls Grace in public school. O'Hara goes into labor.