In the original series, when Nicky and Alex were born, Jesse built a room on the left (from the viewers' perspective) by the stairs and next to the bathroom. In the reboot, their old room is now on the opposite side of the attic where the closet originally was, and is also quite a bit smaller than the original room.
Similar to the original series, Kimmy chastises Danny for not getting the producer's job on "Wake Up San Francisco" and claims he had been on the show longer. In actuality Danny and Becky started at the same time in season 2.
The kitchen and most of the rooms in the house don't match the original sets.
Throughout the series, Jimmy's real name continuously changes. When proposing to be Stephanie's baby daddy, he calls himself 'James "Jimmy" Gibbler". Later in the series, Danny calls him "Jeremiah Jeffcoat Johnson Jimmy Gibbler"
At the start of the revamp in 2016 Nicky and Alex are still underachieving college freshman when they would be 25 years old instead of 18-19 as Jesse claims.
Ramona's last name is Gibbler. Actually, her last name should have been the same as Fernando's and not Kimmy's.