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- Working for the F.B.I., a mathematician uses equations to help solve various crimes.
- The raid on a small time forgers home reveals a secret code book. Don takes the code book to his brother Charlie who tells him that the book hides secrets of a skilled and highly trained assassin somewhere in the country. Interrogation of he forger reveals the name of the intended target, Gabriel Ruiz, the last remaining member of a powerful political family in Colombia. So the hunt begins to catch the assassin before he completes his mission!
- The team investigates a jewelry store theft where the robbers kidnapped the owner's wife and daughter.
- The murder of a young museum researcher sends the team on a search for a killer and a missing Native American skull.
- Don takes under his wing the son of a murdered executive as the team and Charlie try to narrow down who's responsible out of a pool of six thousand or more.
- A series of home invasions become increasingly violent. Charlie's most famous work, The Eppes Convergence, is scrutinized by a former rival.
- When FBI agent Don Eppes finds several murders are linked to counterfeiting, his mathematically genial brother Charlie uses his skills to do what other investigating methods -as used by Agent Kim Hall, Don's colleague and ex in his Albuquerque days, a blank chapter in his past for Charlie- failed to, locate the forging and identify who did the graphical artwork required for his old-fashioned, relatively hard to detect fakes with real printing presses and watermark, not computer printing: it's a missing artist, who must be kidnapped and will probably by murdered as a liability for the counterfeiters...
- A truck of nuclear materials is stolen by terrorists who intend to use the materials to make a bomb which would then be used on the city of LA. Only Charlie and Charlie's father Alan can save the city from a small nuclear blast.
- Charlie and the team investigate a murder at a casino.
- A crime scene drenched in blood leads the team to a form of human trafficking, and Amita to her past.
- When Riley, who practiced an ingenious pyramid method of skimming numerous bank accounts for over half a million dollars, is strangled, exactly the same way -not revealed to the press- as Lisa Bayle, for whose murder Don Eppes' investigation once put Cliff Howard in jail after a plea bargain-confession, Don now fears the wrong man was arrested. Charlie helps him quantify the unlikeliness of a coincidence and seriously doubt the forensic evidence. Electrician Jose Salazar, whom Don suspects, still turns out to be innocent of Lisa's murder, but Charlie realizes that's not the point: what if a third person committed both murders, linked rather by the victims?
- Data from a meth lab explosion reveals a photograph that triggers memories for Charlie and put him at loggerheads with Don who's focused on tracking down the drug dealer who set off the explosion that killed one of his agents.
- When the wife of a judge is killed the team investigates. And they discover that it might not be for the reason they think.
- A prison transport bus crashes after maneuvers by two other vehicles, several inmates escape, including the dangerous McDowd. Charlie gets on well with CHP Officer Morris on the scene and works out mathematically it was no accident, both other drivers probably were in the game. Dad is worried Don might be returning to the period he regularly worked in fugitive retrieval, especially now a former colleague, burly federal marshal Cooper, is on the same case. After finding a lesser fugitive, Charlie's mathematical probabilities approach helps reconstructing the remarkable movements of McDowd in LA, which leads to a worrisome motive relating to a DEA case and likely further accomplices...
- A UFO is briefly seen flying through Los Angeles with no clear indication on what it is, but Agent Eppes discovers it was heading for the Staples Center and starts an investigation into the possibility of mass terrorism.
- A pop star is receiving death threats from an obsessed stalker but Charlie is convinced the letters are written by two different people.
- When a rapist proves a little too difficult to find for the FBI, Agent Eppes and Agent Lake utilize Agent Eppes' genius mathematician brother, Charlie, to discover the rapist's point of origin.
- A genius' (Harris) daughter is captured by two men looking to use his possible solution to a 150 year old math equation for heists.
- An unknown terrorist is mimicking horrible train accidents and leaving a number code at the scene.
- Dr. Larry Fleinhardt's former college days friend Jonas Hoke, the Senior computer-science researcher, who develops for Robert Oliver's firm Lorman group with gifted college drop-out Scott Reynolds a classified program to evaluate government projects, is murdered in his Hollywood Hills home; data were stolen from his computer, which only contains a coded program for analysis of baseball statistics. Hoke's financial divorce complications seem irrelevant, although his wife had a relationship with their security system installer Lucas Grant. However Charlie finds that Hoke actually used the same kind of advanced statistic analysis and performance prediction on other data, cleverly masked under meaningless baseball numbers: Hoke applied this method cutting-edge to calculate human performance prospects in real life, based on various governmental and other data, potentially far more valuable...
- Charlie seeks out an engineering professor to help him recreate a fire scenario to solve an arson case.
- Sniper attacks are occurring across LA but are all the attacks the result of one inexperienced marksmen or is a fad of sniper killings infecting LA?
- When a death results from an anti-terrorism exercise Don and his team are called in, but they end up butting heads with the leader of the unit who refuses to halt further training exercises. Back at home, Alan has volunteered the house for the wedding of a girl both Charlie and Don had a crush on in high school.
- The mysterious suicide of a brilliant but unfocused CalSci engineering major leads Eppes and Charlie to the site of an iconic building.
- Charlie uses math to determine the killer of an undercover FBI agent.
- A few apparently random cases of product tampering lead to a mountain man with a grudge, a pharmaceutical company and a conspiracy.
- A pair of bank robbers are quietly taking LA by storm but Charlie delivers an equation that may predict their next location. But these bank robbers aren't as respectful as the bank videos reveal.
- A deadly virus is spreading through LA and only Charlie's equations can determine how far and where the disease is spreading.
- A psychic helps to find a burial site of numerous illegal immigrants just across the California-Mexico border. Charlie and he battle to see who will come up with the location of another female migrant before she joins the other victims in the morgue.
- The bombing of a recruitment office puts Don and his father at odds, and brings an agent out of retirement.
- When a DNA synthesizer with terrorist possibilities is stolen from a university lab, Charlie and the team must find it before it leaves the country.
- After an Iraqi woman - in the US to film an interview on atrocities against women back home - is murdered, clues lead to an American military suspect and the team must determine their truth before another killing occurs.
- An ATF agent is found in her home, an apparent victim of suicide. Don, having been involved with her, asks Charlie to run algorithms to determine if she was likely suicidal, or she was murdered.
- Charlie helps the team solve how many shooters there were in a school massacre.
- The Russian mob threatens Don and his family, however Charlie refuses to give up working the case.
- After an assailant opens fire in the FBI offices, Charlie does not want to return.
- Don's team investigates a rapist who's converted to a serial killer, as Charlie struggles with memories of his mother.
- The bodies of young Asian girls wash up on the beach, including one with bird flu. Amita gets a job offer.
- Charlie and the team track a couple who are spree killers, but their actions seem to defy profiling.
- The team is in a race against time to rescue fellow agent Megan from the clutches of Crystal Hoyle.
- Charlie and the team grapple with the concept of 'randomness' while trying to find a killer targeting drivers on the freeway.
- The hit-and-run death of an interpreter may compromise a team member, and Charlie must deal with not being consulted for a paper.
- The robbery of a painting that unexpectedly turned to murder, has the team exploring a disputed provenance and possible insurance fraud.
- Blackouts all over Los Angeles leave the city in the dark. Don works with his team to figure out if the power outages are an accident or the work of terrorists.
- The death of a minor league player leads to a math prodigy and stirs old feelings for Don.
- Don and the team investigate a suspicious death at a horse track. When Charlie starts looking into the crime, he uncovers something that will send the investigation into an entirely different direction.
- Charlie's investigation of a company's toxic paving material is impeded by a new school administrator who wants him to focus primarily on his pure academic work instead.
- The assassination of a California senator leads the team to questionable experimentation on prisoners, the CIA, and a man bent on revenge. Elsewhere, Larry makes an announcement that shakes Charlie.
- The team tries to track the person murdering men in homes that are for sale, and Larry's dream of space may be in jeopardy.
- The search for a pedophile polygamist takes an interesting genealogical turn when a quilt is found.