The McDonald's scenes were all shot in City of Industry, CA, just outside Los Angeles. The set was a real-life McDonald's built specifically for crew member training and television commercials. Everything inside worked, but it never served a real customer. When it wasn't being used, it was locked up behind a chain link fence. It was torn down and rebuilt in 2006.
Whenever Paul Rudd appeared on Late Night with Conan O'Brien (1993), he would pretend to have brought a clip from his newest film, but he would always instead show the scene from Mac and Me of Eric rolling off a cliff and falling into the water. Rudd has done the joke for many years, even when promoting Ant-Man (2015). The first time he showed the clip, he was promoting Friends and promised to show a scene from the final episode; coincidentally Jennifer Aniston does have a small role in Mac and Me. In 2022 he was a guest on Conan O'Brien's podcast. As this was a strictly audio medium, Conan was caught totally by surprise when, after a long and involved story from Rudd about a non-existent project he claimed to be working on, he played the same Mac and Me clip.
As a criticism of the film's gratuitous product placements, the Razzies awarded Ronald McDonald the prize of Worst New Star. As of 2020, Ronald is the only fictional character to win a Razzie.
Part of the film's box-office intake was donated to the Ronald McDonald House Charities.
Jennifer Aniston: as an uncredited extra, sitting on a curb, watching the dancers in the McDonald's parking lot.
Nikki Cox: as an uncredited extra during the birthday party scene at McDonald's. She's a little redhead girl wearing a yellow shirt and white shorts.