While returning suspected killer Pruit Dover to Dodge to stand trial, Matt is shot and badly wounded, and yet Dover stays with him and nurses him back to health.
Mace Gore's gang has taken over Dodge. When Matt is believed killed, Festus and Doc have a plan to lure Gore into a trap, even though his usual plan is to leave by dawn.
Childless and poor, farmer Caleb feels like a failure, and his wife assures him he is one. Caleb moves into town to seek some meaning in his life, and soon finds himself--a man who doesn't wear a gun--challenged to a duel.
The arrival of the first woman doctor in Dodge City, Dr. Sam McTavish, riles Doc Adams. However, she soon wins his confidence and that of his patients, and the two physicians make a startling medical discovery.
A headstrong young woman will undertake the long, dangerous journey to her fiancé's fort on her own if she must, so Matt nominates himself to escort her.
To escape a potentially lethal blizzard, Matt seeks shelter in a cabin in which two psychopathic bandits have enslaved and repeatedly molested a young woman after murdering her father.
Mannon, arguably the fastest gun in the West, terrorizes Dodge City while he waits for Matt Dillon to return. A cruel, violent encounter with Kitty Russell sets up the inevitable showdown.
A young man is convicted of killing the saloon girl he wanted for his own. Matt is so sure that the young man is really innocent that he goes on the road after another suspect to prevent an unjust hanging.