- Elder sister Yetunde Price was murdered in Compton, California in Fall of 2003
- At age 35 and already about 2 months pregnant with her daughter: Olympia, Serena beat her sister: Venus Williams in the final of the Australian Open in January 2017, clinching a record 23rd Grand Slam singles title.
- She, Martina Navratilova, Steffi Graf, Margaret Court, and Maureen Connolly are the only women in tennis history to hold all four Grand Slam singles titles at the same time (2002).
- Speaks French well enough to do press conferences in the language.
- Is the youngest of 5 girls.
- Lives in Palm Beach, Florida with her sister, Venus Williams, and two dogs, Jackie (a Jack Russell terrier) and Lauralie (a Maltese). They became limited partners of the Miami Dolphins. (2009)
- She is a certified Fashion Designer and has her own clothing line called "Aneres" which is her name spelled backwards.
- She has three half sisters: Lyndrea, Isha & Yetunde (deceased).
- On 25 January 2003, she won the Australian Open tennis championship, completing the 'grand slam' of women's tennis. "The Serena Slam Completed" was ranked #10 in TV Guide's list of the "25 Most Awesome Sports Moments (of the last 15 years)". [17 July 2005 issue]
- Dad Richard is her coach.
- Her scenes of her first movie Black Knight (2001) were cut.
- Was the 1999 US Open champion.
- Younger sister of Venus Williams.
- Won the 2000 Olympics doubles competition with her sister Venus
- Release of her book, "How to Play Tennis: Learn How to Play Tennis with the Williams Sisters" by Serena and Venus Williams. (2004)
- One of Time Magazine's 100 Most Influential People in the World. [April 2014].
- Has endorsements with Nike, Wilson Gatorade, OPI, Tampax, Hewlett-Packard, Kraft and Puma.
- Career prize money as of (2017) is $84 million, making her the highest-paid female athlete in the world, having won 86% of her matches.
- Recently won the Sony Ericsson Open for the 4th time in her career. Crushed the tournament's top seed Maria Sharapova 6-1, 6-1 in the 4th round after Sharapova had defeated older sister Venus Williams. Made a dramatic comeback in the final against newly crowned world number one Justine Henin. Defeated Henin 0-6, 7-5, 6-3 in the final. Continues her remarkable comeback to the top of the tennis rankings. Ascended from 95 in the world last year to number 11 by winning the two biggest titles of the year so far. (March 2007)
- Among her pets was a Yorkshire terrier by the name of Petey (named after one of her tennis heroes, Pete Sampras), Jackie the Jack Russell Terrier; and Bambi the pitbull.
- Appeared in an infomercial, hosted by Anthony Robbins and Tom Selleck, for "The Tony Robbins Ultimate Edge" system. (2008)
- Appeared in an infomercial, hosted by Vanessa Williams, for "Proactiv Solution" acne medication. (2007)
- Release of her book, "On the Line" by Serena with Daniel Paisiner. (2009)
- Unable to defend Australian Open title (lost in the third round). Missed the French Open and Wimbledon due to injuries and attempted a comeback at the US Open but lost in the 4th round. Only competed in 4 tournaments in 2006. Ranking has dropped to 95 in the world. (September 2006)
- Has two daughters: Alexis Olympia Ohanian Jr. (b. September 1, 2017) and Adira River Ohanian (b. August 22, 2023) with husband, Alexis Ohanian.
- In 2016 she met husband-to-be Alexis Ohanian by chance in her hotel during a visit to Rome, one of her favorite cities.
- Reestablished herself as the dominant force in women's tennis by winning the Australian Open for the 3rd time. Dominated the world's top ranked player Maria Sharapova in the final 6-1, 6-2 to win her 8th major championship title. (January 2007)
- Daughter of Richard Williams and Oracene Price.
- Has dropped to #6 in the rankings. Has not played in a tennis tournament since July, 2003. She dropped off the tour due to knee injuries, but despite her recent announcement that she is healthy and fit she decided to withdraw from the Australian Open grand slam competition (where she is defending champion) as she continues to pursue TV and film appearances. (February 2004)
- Appeared naked and pregnant on the August 2017 cover of Vanity Fair magazine, continuing a trend begun by Demi Moore with the May 1991 issue.
- (November 16, 2017) Married her boyfriend of 2 years Alexis Ohanian in New Orleans following a 10-month-long engagement. They have 2-month-old daughter Olympia together.
- Recently won her 7th major title at the Australian Open Came back from match points down to defeat reigning Wimbledon champion Maria Sharapova in the semifinals then went on to defeat top seed Lindsay Davenport in the final. (January 2005)
- Release of the book, "Venus and Serena Williams: Athletes" by Anne M. Todd. (2009)
- Besides tennis, Serena doesn't like to work out much.
- In 2007, Forbes Magazine estimated her earnings for the year at $14 million.
- Attended the Royal Wedding of friend Meghan Markle & Prince Harry in a draped pink Gianni Versace dress (Windsor Castle, UK / 19 May 2018).
- Has a small feud with fellow tennis player Jelena Jankovic about the amount of time the players should have to practice.
- Her Net Worth is $24.6 million.[Jan 2017].
- Her pregnancy craving is green vegetables.
- Friends with Andy Roddick, Brandy Norwood, Kelly Rowland, Eva Longoria, Meghan Markle, and La La Anthony.
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