- Not related to José Ferrer, or José's son Miguel Ferrer. However, his son with Audrey Hepburn, Sean Hepburn Ferrer, had only one acting role, with Audrey in They All Laughed (1981), portraying a man named "Jose," meant to be a Hollywood inside joke.
- Brother of famous cardiologist and educator Dr. M. Irené Ferrer. She helped refine the cardiac catheter and electrocardiogram, which have become diagnostic essentials in heart treatment.
- Wife Audrey Hepburn did not want to be separated from her husband while filming Funny Face (1957), so filming of the Paris scenes was timed to coincide with Ferrer's filming of Elena and Her Men (1956).
- Father of Sean Hepburn Ferrer with Audrey Hepburn.
- Directed José Ferrer (no relation) in the latter's first performance as Cyrano de Bergerac.
- Officialy retired from acting on his 80th birthday in 1997 and took up residence in Lausanne, Switzerland.
- After divorcing his first wife, Frances Pilchard, he married Barbara Tripp. He then divorced Tripp so he could remarry Pilchard.
- After attending Princeton University until his sophomore year, he abandoned his studies and worked as an editor of a Vermont newspaper. He also wrote a children's book named "Tito's Hat".
- Born to a Cuban-born father, a surgeon, and his wife, a New York socialite, he grew up in New Jersey.
- His oldest child, with Pilchard, died as an infant.
- Father of five children: Pepa Phillippa (born on 19 August 1941) and Mark Young Ferrer (born on 19 June 1944) with Frances Pilchard, Mela (born on 22 January 1943) and Christopher Ferrer (born on 4 February 1944) with Barbara C. Tripp, and Sean Hepburn Ferrer (born on 17 July 1960) with Audrey Hepburn.
- Spoke Spanish and French fluently.
- Prior to his marriage to Elizabeth Soukhotine, Ferrer had a scandalous relationship with 29-year-old interior designer/shipping heiress Tessa Kennedy, who was still married to her first husband Dominick Elwes.
- Member of the jury at the Cannes Film Festival in 1962.
- In 1947, Mel Ferrer, along with Dorothy McGuire and Gregory Peck, founded the "La Jolla Playhouse", In La Jolla High School, La Jolla, CA. The name "La Jolla Playhouse" is now applied to a theater complex on the campus of the University of California in San Diego, California.
- Made his Broadway debut as an actor at age 23, two years after making his debut as a dancer aged 21.
- Pepa Phillippa Ferrer, his second child with Frances Gunby Pilchard, was conceived after their divorce and before their 2nd wedding, while he was married with Barbara C. Tripp, and even before the birth of his children with Tripp.
- Appears in two films called Eaten Alive: Eaten Alive (1976) and Eaten Alive! (1980).
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