The film's producer met with Elizabeth Holmes early in development, before criminal charges were filed, to determine whether she could be interviewed for the film. Ultimately the director decided he wanted to portray how Holmes carefully crafted Theranos and her own image to be seen by the public, up until the story unraveled. Accordingly, aside from brief footage from her deposition, all footage of Holmes seen in the film is from archival material from before she was charged, most of it her own commissioned promotional video for Theranos. Alex Gibney remarked "She made the documentary she wanted me to invest in and I used it to a different purpose."
Holmes, the Theranos founder, faced up to 20 years in prison for each of four counts that led to a conviction in her federal fraud trial. Elizabeth Holmes, the Silicon Valley start-up founder convicted of fraud, will be released in September 2034
There have been audio clips posted online that show Elizabeth Holmes, Stanford University dropout faked her voice to sound more authoritative in a male-dominated industry.