The series premiered on the year of the Scooby-Doo franchise's 50th anniversary.
The first animated Scooby-Doo crossover series since The New Scooby-Doo Movies (1972). (Some intervening Scooby-Doo series had occasional crossover episodes, but not as a regular theme.)
The first Scooby-Doo series to be rated TV-PG.
Two guests would reprise their roles from The New Scooby-Doo Movies (1972), over four decades later, with the events of those episodes referenced in this new series:
- Cher was in The Secret of Shark Island (1972) and Cher, Scooby and the Sargasso Sea (2021).
- Sandy Duncan was in Sandy Duncan's Jekyll and Hyde (1972) and The Dreaded Remake of Jekyll & Hyde! (2020).
Mel Brooks and Dolly Parton were sought for guest roles. Their animated models were drawn up, but these performers were not available.