Cisco states that giving the cure to Cicada in a month would be very fast for them to stop a villain. This is a fourth-wall reference to the fact that it takes a full season for Team Flash to defeat each main antagonist.
Barry teaches Nora about time travel, using the example of a coffee cup being like the space-time continuum, breaking whenever you travel through time, closely quoting what Jay Garrick had told him about the consequences of time travel in Paradox (2016).
The episode's title is a play on the phrase "cause and effect," and a reference to Cause and Effect (2017).
The animation when Nora runs back in time is somewhat similar to the animation of Barry being thrown through time in Fast Forward (1991).
This is the first episode since Seeing Red (2019), and the third since The Icicle Cometh (2018), to feature Cecille, despite Danielle Nicolet being credited as a series regular.