After Stewie makes a 9/11 joke, Brian says he was supposed to be on one of those planes, where Stewie replies that he was as well. In real life, Seth MacFarlane (creator of the show and voice actor of the characters mentioned) was supposed to be on one of the planes, but missed his flight by a few minutes because his travel agent told him the wrong departure time.
Amanda Seyfried's guest-starring role in this episode was due to having worked with Seth MacFarlane in A Million Ways to Die in the West (2014) and Ted 2 (2015).
Meg doesn't appear in the episode. She does appears at the end in the musical ensemble.
For unknown reasons, despite the Valentine's Day-themed plot, the episode aired on January 7, 2018, possibly due to the Grammy Awards and the Winter Olympics.