Starting from this episode, the opening has been slightly modified to include both Gizmoduck and Magica De Spell, replacing Big Bulb firing the laser and one of the Beagle Boys in the close-up of the villains.
The plot involving a microscopic civilisation with their own shrink ray was also used in the episode "Micro Ducks from Outer Space" from the Original DuckTales (1987), and the plot involving a battle against a microscopic civilisation was also used in the film Small Soldiers (1998).
The theme to the Original DuckTales (1987) can be heard as Huey and Scrooge mantra their way through the traps.
The title is a reference to the book "The Most Dangerous Game" by Richard Connell, along with its many film adaptions.