The final scene in Cartman's basement is taken almost directly from a promotional video for South Park: The Fractured But Whole shown at E3 earlier in 2017. Only a few snippets of dialogue were changed. The game was released six days after airing.
Zuckerberg's Dialogue is in the dubbed style of 1970s Kung Fu movies as are his lines. It may also be a reference to his 2017 tour of hurricane-struck Puerto Rico in virtual reality.