When confronting the White Martians, Kara claims that she missed "a left turn at Albuquerque", referencing a classic line by Bugs Bunny.
J'onn and his father discuss the Martian lore of H'ronmeer and his sons Phobos and Deimos. In addition to being the names of Mars' moons, Phobos and Deimos are, in Greek mythology, the sons of Ares, the counterpart of Mars, the Roman god of war.
J'onn's father is portrayed by Carl Lumbly, who voiced the Martian Manhunter in four DC animated series: Static Shock (2000), Justice League (2001), Justice League Unlimited (2004), and Justice League: Doom (2012).
As Kara confronts the White Martians, the song "...Baby, One More Time" by Britney Spears is playing in the background. In the music video, "Oops, I did it again", Britney Spears is on Mars, which is where they are in the episode.
When J'onn Jonzz and Supergirl are flying to Mars in his spaceship, they breeze past the far side of the moon showing lights for the moon base.