Wyatt, Matt Lanter's character makes a comment at the end of the episode "You can call it fate or God or the Force" Matt would know all about the Force, as he is the voice of Anakin Skywalker in Star Wars - The Clone Wars
Jim Beaver, the new NSA agent in charge is also known for being on Eric Kripkes other production Supernatural (2005) as Bobby Singer, the Winchesters surrogate father.
Actor Jesse Luken (playing Charles Lindbergh) was also in the CW show, Star-Crossed with Matt Lanter (plays Wyatt Logan).
The remark that is made to Ernest Hemingway in 1927 Paris about having read all his books when he then had published just one is a direct quote from Woody Allen's :Midnight in Paris" when Owen Wilson says the same thing.
As of 2022, both Susanna Thompson and Anne Wersching have both played a version of the Borg Queen in a Star Trek franchise.. Susanna in Star Trek: Voyager and Anne on Star Trek: Picard.