By crossing over with Hawaii Five-0, Macgyver is now firmly placed in the same TV Universe as JAG, all three NCIS series, and Scorpion.
This is a crossover episode with Hawaii Five-0 with only a few characters from the show.
MacGyver refers to Einsteins theory of insanity, which in popular culture is "doing the same thing over and over again and expecting a different result." However, this has never been a definition of insanity, by Einstein or anyone else.
Daniel Dae Kim and Grace Park both appeared on CSI: Crime Scene Investigation, which co-starred George Eads. Kim guest starred in the season two episode Ellie, while Park had a cameo in the season nine episode A Space Oddity.
The dog's name in real life is Cruiser.