Sheldon saying to Amy, "You truly are a Goofus to my Gallant," is a reference to Highlights Magazine, a monthly magazine for children.
The Goofus and Gallant comics are intended to teach good manners and social behavior. Gallant is polite, considerate, and generous. Goofus is selfish, rude, inconsiderate, and bossy. In fact, Sheldon is almost definitively Goofus.
First appearance of Raj's dog Cinnamon since the seventh season.
The name "Bloberta" is used in reference to a baby's name. "Bloberta Puppington" is a claymation character on the Moral Orel (2005).
First appearance of Howard and Bernadette's remodeled bedroom.