Features patient Katie Bryce, who made her first appearance in the pilot, where she was Meredith's first patient ever. This makes her the character with the biggest gap between two appearances.
The song Into The Fire by Thirteen Senses also plays in this episode as it does in Season 1 Episode 1 when Derek Shepherd is operating on Katie Bryce.
This episode's title originated from the song My Next Life, originally sung by Merle Haggard.
This episode scored 7.67 million viewers.