This was the first film produced by a major Hollywood studio to feature a gay teenage protagonist.
Jennifer Garner's "exhale" speech wasn't originally in the script; there were just a few "parent scenes". When Garner became interested in the role of Emily, she asked director Greg Berlanti for a scene that has her actually connect with Simon, so they built it again and wrote what would become essentially the message of the film.
Director Greg Berlanti revealed in an interview that there were clips of the "friend group" (Simon, Leah, Abby, and Nick) that were filmed without the actors' knowledge. In order to capture the authenticity of a group of friends beyond the confines of acting, the director would sometimes tell the actors to "cut" but have the cameras keep rolling. Many of these unscripted interactions of friends just being friends (including the dancing in the car scene) made the final cut.
In Simon's bedroom there is an Elliott Smith poster, which is a nod to Simon's favorite musician in the book, which he shares with Blue and later connects with Blue over.