Buzz Milk is based on Fairlife, a milk beverage sold by the Coca-Cola company that received mostly negative reviews from nutrition experts.
On the Latin-American dubbing, Skinner's real last name is Barreda (instead of Tamzarian), so when Miss Berreda (Sofía Vergara ) was introduced many thought it could be Seymour's long lost daughter or sister.
Principal Skinner mentions that Ms. Berrera's cat is named Bowie. In a twist of fate, this episode aired on the day of Bowie's death. Additionally, David Bowie had two different colored eyes, just like the cat in question.
The title is a reference to "Teenage Mutant Ninja Turtles".