The opening exterior scene was filmed at 380 South San Rafael Avenue in Pasadena, California. This was the same exterior shot used as Wayne Manor in Batman (1966).
Powers Boothe, who plays Gideon Malick, played Reverend Jim Jones in Guyana Tragedy: The Story of Jim Jones (1980). In discussing Giyera's faith in Hive, Mack snickers, "Wow. You've really drunk the Kool-Aid," which is how the real Rev Jones' followers were trained to commit suicide rather than be captured--by drinking poisoned Kool-Aid. While this is a popular saying, it is not 100 percent accurate, as the actual drink mix was a combination of Flavor Aid and Kool-Aid.
A Wilhelm scream can be heard when Lincoln zaps James.
In 2009-2013, Luke Mitchell and Axle Whitehead worked together in the Australian soap Home and Away (1988). Axle played Luke's friend and mentor Liam.
"Paradise Lost" originally aired on ABC on April 12, 2016, and according to Nielsen Media Research, was watched by 3.01 million viewers.