Daisy mentions having Damage Control come to clean up the Mackenzie's house after the shootout. Damage Control is a construction company appearing in Marvel Comics, which specializes in repairing the property damage caused by conflicts between superheroes and supervillains.
Daisy Johnson offered to "quake" the Nitramene off Fitz's neck, which is a reference to her code name from the comics, "Quake."
Daisy calls Mack and Fitz the 'Nerd Herd', this is the name of the team in the civilian cover job for Chuck, a regular citizen turned super spy, in Chuck (2007).
Gaius Charles appears on the show for the first time as Mack's brother. Adrianne Palicki (Bobbi Morse) starred on the show until this episode. Both Charles and Palicki have starred on Friday Night Lights (2006).
"Watchdogs" originally aired on ABC on March 29, 2016, and according to Nielsen Media Research, was watched by 3.20 million viewers.