"You only turn 80 once. Or, in the case of most people, not at all." Marge says this about her mother, but it's not true. Grandma Bouvier had an 80th birthday celebration in Season 21 as well, this one hosted by the Simpsons. Moe was there serving non-alcoholic beer.
It is revealed that Clancy Bouvier died of lung cancer likely because he was a smoker.
This is the first time Patty and Selma give up smoking.