Jennifer Goines wears the same sweater in this episode that Brad Pitt wore in the original movie Twelve Monkeys.
The claymation clip that's playing in the J.D. Peoples Mental Institution is 'The Mysterious Stranger' sequence from the 1985 film 'The Adventures of Mark Twain'.
The asylum is called J. D. Peoples. Two of the writers for the movie "12 Monkeys" were Janet and David Peoples.
When Cole and Ramse return from their excursion at the beginning of the episode, they are scanned in a room and the sound effect is the same as a tricorder from Star Trek: The Next Generation
Jones tells Cole she was 37 years old when the world died. Since the virus was released in 2017, that means Jones and Cassandra were born in the same year, 1980.