At the end of the episode when Nathan is speaking to his mother in the background is a "Luney Toonz" poster. It clearly shows the 2 Looney Tunes characters Rocky and Mugsy who Nathan and Mimsy appear to be based on.
Other than a framed picture of Kyle being visible in the background of one shot, none of the 4 main characters appear in this episode. However, they do appear in a deleted scene from the episode. The scene is included on the season 18 home video release.
This episode pays homage to Hanna-Barbera's "Wacky Races" and features sound effects and characters inspired by the series. Dick Dastardly and Muttley also appear, Muttley's laughs are provided by the show's original recordings by Don Messick.
Nathan and Mimsy's first appearance since Season 14's Crippled Summer (2010)
Matthew McConaughey driving the Handicar and then the Zipcar in the Wacky Races is a parody of his Lincoln MKC car commercials. "I was driving a Handicar way before I got paid to drive one."