Soos not knowing how to pronounce "Giffany" is a reference to Gifs, which no one really knows how to pronounce.
The title is a reference to Lars and the Real Girl (2007), a film about a man struggling with his romantic life in a similar fashion to Soos in this episode.
The password to Soos's computer is FIXINIT1.
If Soos had chosen option "Shizenhakka" on first playing "Romance Academy 7" it would have been a much shorter episode as that word roughly translates to "Spontaneous Combustion"
Alex Hirsch confirmed on his Twitter that Giffany's name is technically spelt as ".GIFfany", to sound more like a pun toward a .GIF file format.