At one point, due to the amount of fake blood being used, production bought all of the corn syrup available in Kirkland Lake, Ontario. There was nowhere in town to buy any corn syrup for two days.
When the screenwriter's mother read the first draft of HOLY HELL her immediate response was: "Don't show this to anyone." Despite her initial horror, she ended up costume designing for the project.
Multiple actors, due to the subject matter, requested that their real names not be used in the credits. They chose stage names to protect their identities.
Ryan LaPlante wrote this film immediately after directing a production of the stage musical RENT. He's quoted as saying "After working on something so sensitive I just wanted to write the least sensitive script I could. I think I succeeded."
Shane Patrick McClurg, the actor who played Sissy MacFarlane, created his own makeup design.