Contains what is supposed to be the final Chuck Lorre Vanity Card, #463, the vanity cards which are shown during the end credits of Chuck Lorre's television shows. Chuck Lorre has since reneged and there is a #464.
The Capitol Comics Store seen in this episode is the same one visited by Stuart and Bernadette in The Occupation Recalibration (2014), although the obnoxious owner Jesse (Josh Peck) is absent this time.
Title Reference: Emily's reaction to Penny, which is the consequence of Penny and Raj having spent the night together three years ago, in The Roommate Transmogrification (2011).
Sheldon mentions he fears dinosaurs and chickens, another reference to the story from his childhood where he was chased into a tree by an angry chicken (as told in The Jiminy Conjecture (2009) and The Cruciferous Vegetable Amplification (2010)). Additionally, all birds are considered dinosaurs, and as a chicken is a bird, it is also a dinosaur, so Sheldon is basically afraid of 1 thing, not 2 different things.
Howard has a problem with his mother buying Stuart "7 HBOs" while he's taking care of her. The Big Bang Theory is available on HBOMax.