During a role-playing game, Debbie says that she will "cast Magic Missile to attack the darkness." This is a reference to the "Dungeons and Dragons" sketch by comedy group The Dead Alewives, in which an inept player is desperate to cast Magic Missile in a dark cavern even though there is no enemy around to fight; in response, and to the amusement of all other players, he proclaims, "I attack the darkness!" It's notable that this sketch is a parody of the same religious backlash against role-playing games that the Jack Chick tract "Dark Dungeons" was based in.
During one scene Mistress Frost says "the evil undead lich Xykon" possibly a reference to the Order Of the Stick an online Dungeons and Dragons webcomic by Rich Burlew