Every episode this season is titled after a song.
There is a four month time jump after the events of Season Five's finale, Home, which places the start of Season Six in September 2012 in the series timeline.
Alaric returns as a series regular in this episode for the first time since The Departed after being resurrected in Home.
This is the third season premiere episode in which Elena starts out single. The first was the Pilot episode of Season One (also the series first episode). The second was Season Three's The Birthday.