- Sherlock Holmes: [to Watson, re Moriarty] The woman is a riddle wrapped in a mystery inside an enigma I've had sex with. I would be lying if I said I was the strongest assessor of her motives at this point.
- [Moriarty is lying on the floor, bleeding from a gunshot wound]
- Jamie Moriarty: Your letters have meant a great deal to me. I find them influencing my decisions in the most surprising ways.
- Sherlock Holmes: You could have killed Agent Mattoo. And from your perspective, it would have been the expedient thing.
- Jamie Moriarty: And yet, to you, it would have been repugnant. Tell me, is that how you learned to be one of them? By learning to care how your actions seemed in the eyes of another?
- Sherlock Holmes: ...I'm not sure I am one of them.
- Sherlock Holmes: [v.o] We have spilled much ink, you and I, in our discussion of human connection, and we're no closer to understanding than we were when our correspondence began. I often feel as if I am standing on one side of a wide chasm, shouting across, and wondering if the response I hear comes from you, or if it is my own voice, echoing back to me. It seems to me, on my side of the canyon, the search for unity with another is the font of much of the world's unhappiness. I watch as Watson, eager as ever to extract some meaning from the prevailing social conventions, endures a series of curated mating rituals. It seems to me that she's incrementally... less content each time she returns from one. I conduct myself as though I'm above matters of the heart, chiefly because I have seen them corrode people I respect. But in my candid moments, I sometimes wonder if I take the stance I do because "love", for lack of a better word, is a game I fail to understand, and so I opt not to play. After all, if I truly had the purity of all my convictions, I wouldn't regret so many of the things I've done, nor would I persist against many of my better instincts in this correspondence. I find you a challenge; one that, in spite of all that you've done, continues to stimulate. And so the conversation - futile though it may finally be - continues. And we are left to wonder, have we simply failed to find the answers to the questions that preoccupy us, or can they not be answered at all? Fortunately for both of us, the world always presents the next diversion, the next elaborate distraction from the problems that vex.
- Sherlock Holmes: Did you say everything you wanted to say today? To Moriarty? That is why you accompanied her to the Fuller residence, is it not? So you would have a private dialogue with her?
- Dr. Joan Watson: Well, you have been hogging her for the last few months.
- Sherlock Holmes: I told you. I have merely been...
- Dr. Joan Watson: Studying her. Right. You have feelings for her, and that is perfectly normal.
- Sherlock Holmes: I have nothing of the sort.
- Dr. Joan Watson: Irene was the love of your life. That is why, in spite of everything, you can't quite give her up. I get that. But I also know that you're only gonna get hurt in the long run because there is no Irene. There is only Moriarty. And Moriarty is never gonna change.
- Jamie Moriarty: Would you be surprised to learn you've been on my mind, Joan Watson?
- Dr. Joan Watson: Not really.
- Jamie Moriarty: I don't typically misread people, but you're more clever than I initially anticipated. More interesting. If you weren't, I would never have been caught.
- Dr. Joan Watson: I think you give me too much credit.
- Jamie Moriarty: It's what you crave, is it not? Acknowledgment from a superior mind. Evidence that you matter. Why else pursue a partnership with a man like Sherlock?
- Dr. Joan Watson: Actually the partnership was his idea. That bothers you, doesn't it?
- Jamie Moriarty: I confess I don't understand it, but I'm drawn to things I don't understand. Same as Sherlock. Once I've figured you out, I'll move on. Same as Sherlock.
- Dr. Joan Watson: Is that why you've been writing him? Because you want to... understand him?
- Jamie Moriarty: Part of it, I suppose.
- Dr. Joan Watson: And the rest?
- Jamie Moriarty: What do you think?
- Dr. Joan Watson: You think you're in love with him. Only you can't be sure, because as much as you claim to know about the world, love is something you don't quite get.
- Jamie Moriarty: You'd be surprised what I'd do for love.
- Dr. Joan Watson: Nothing crazy people do surprises me.'
- Jamie Moriarty: I write to Sherlock because he's the only person on the planet I can really talk to. He writes to me because I'm the only one he can talk to. The only one he can ever truly relate to. If you still don't understand that, you will someday. I promise.
- Ramses Mattoo: She has been equipped with special security bracelets, like handcuffs that are not connected.
- Sherlock Holmes: Handcuffs that don't connect. Shoot me now.
- Jamie Moriarty: Would it surprise you to learn that during the course of my internment here, I have devised exactly 17 means us escaping, 6 of which can account for the extra precautions like my... bracelets.
- Ramses Mattoo: I can only come up with... 10.