Miss Divine was written specially for Amanda Lepore.
Rossy De Palma was original cast as Dora Ramona Del Pilar, and later as Olvido Buenaventura, but finally she had to drop out due schedule conflicts.
Haydée Balza and Mimi Lazo were considered to play Dora Ramona Del Pilar and Olvido Buenaventura, respectively.