This episode was intended as a backdoor-pilot episode for a spin-off series called Supernatural: Bloodlines. Unfortunately, the spin-off never made it off the ground as this was the show's lowest rated episode in 9 seasons.
Sam and Dean use the FBI aliases of Bonham and Peart, a possible reference to John Bonham and Neil Peart, drummers for Led Zeppelin and Rush, respectively.
Unlike other shifters in the series, the ones in this episode didn't have to shed their skin in order to shapeshift into someone else.
Lowest rated episode of the series so far
Sean Faris plays a werewolf in this episode but played a vampire in The Vampire Diaries (2009), another extremely popular CW television series.