Title meaning: a reference to either Hayley (who is stuck in New Orleans because of her yet-unborn child with Klaus), Davina (who is trapped in New Orleans at the heart of the power struggle between vampires and witches), or Camille (who has moved back to New Orleans after an extended absence to discover the reasons behind her brother's unexpected massacre of his fellow seminary students and his subsequent suicide).
This episode had about 2.23 million viewers in USA, which was 0.01 million more than the previous episode.
Girl in New Orleans is the name of a 1972 song by Sammi Smith.