The brand of cigarettes that Mrs. Martinez smokes, Morley, is not a real brand, but it has been a popular fake cigarette brand in TV shows and movies since 1960, when it appeared in Alfred Hitchcock's movie Psycho (1960). Perhaps its best-known use was as the brand preferred by the "Cigarette Smoking Man" on The X-Files (1993).
John Hurt portrayed Abraham Setrakian in the original pilot. Due to other commitments, he was unable to continue in the role.
Based on the first of a trilogy of books written by both Guillermo del Toro and Chuck Hogan. The second book is The Fall and the trilogy concludes with The Night Eternal.
The name Eldritch Palmer (Jonathan Hyde) originates from Philip K. Dick's 1965 novel "The Three Stigmata of Palmer Eldritch". In it, three body parts of the titular character had been artificially augmented or replaced. The series' character is also portrayed as having undergone surgical transplants. In addition, the author of the novel describes the augmentations as symbols for alienation, blurred reality and despair - states of mind that Eldrich Palmer seems to be familiar with.