Many characters in shows usually have names that describe their character or are references to their characters inner self. For example; Miles Matheson, who is "good at killing" is a soldier. His first name, Miles, is a derived name from Latin, where Miles in Latin means soldier, or legionnaire.
Show creator Eric Kripke was born and raised in Sylvania, Ohio, a suburb of Toledo. Many names from that area feature in the show, including the neighborhood the main characters live in at the beginning of the series, Sylvania Heights.