As it's common in media, Queen Isabella is played by a raven-haired actress, but the real one was blonde.
Magnesium was not available as a metal until the early 1800s.
Queen Isabella's highly anachronistic outfit includes high heels, transparencies and a high 'peineta' that only came to being in the late 18th century.
Clarice Orsini claims that Ferdinand and Isabella "Currently [...] wage war with Portugal, while facing civil uprisings at home." At the time, Ferdinand and Isabella were fighting a war of succession with Isabella's niece Juana, who was indeed backed by Portugal, but Juana's support within Spain cannot be called an "uprising" because the people backing her had never sworn fealty to Isabella and Ferdinand in the first place.