Spider-Man and his team face Doctor Octopus again, they discover that Doctor Octopus is replicating animal DNA at his secret hideout. Spider-Man and Dr. Connors discover there is several types of animal DNA, Connors becomes interested with the Lizard DNA and he tests the DNA on himself. Connors discovers that the DNA has restored his missing arm, which he lost during the Goblin's attack on the S.H.I.E.L.D Helicarrier. Connors starts taking more doses of the Lizard DNA and he becomes an irrational reptile hybrid known as The Lizard.
—dawsonpersi