The beginning of this episode starts with House looking through the eyes of a picture of Stephen Colbert, one of several references both Hugh Laurie and Stephen Colbert have made about each other on their respective shows.
Having taken LSD drugs, Dr. Chi Park hallucinates Chase is Roger Rabbit, and Dr. Jessica Adams is Jessica Rabbit with sexy red hair and a big bust. As Park remarks that "they're married," this refers to the "Roger Rabbit" films.
Will references Ross & Rachel from the sitcom Friends (1994). Hugh Laurie was in an episode of Friends (1994) staring opposite Rachel (Jennifer Aniston) in the season four finale 14 years earlier.
Will says, "Like Rachel and Ross on Friends." refers to the third season of the NBC TV series Friends when Rachel decides that she and Ross should have a break. As a result, Ross sleeps with another woman, Rachel finds out, and they break up. Their relationship was never fully reestablished until the series finale, seven years later.
Billy Connolly's character voices support for House's green card marriage to Dominika. Billy Connolly previously starred in the short-lived sitcom Billy in which he played a Scottish teacher who enters into a green card marriage to stay in the US.